The Sangokoya Lab, (PI: Carolyn Sangokoya, MD, PhD) focuses on how post-transcriptional regulatory networks (RNA + RNA-binding proteins) drive cell fate, function, and plasticity. We use functional and spatial transcriptomics, quantitative cell biology, gene-editing, and biosensors to understand the role of iron (and more) in development and disease.  We are developing functional ‘omic methods for understanding how post-transcriptional regulatory networks alter cell fate, function, and plasticity in 3D stem cell-based models and in mice.  

Finally, we apply an RNA-based lens to better understand human liver tissue in health and disease. Our long term goals are to apply our findings to re-engineering cells for regenerative therapies and to innovating diagnostic liver pathology in the age of precision-based medicine.  

POST-TRANSCRIPTIONAL REGULATION IN PLURIPOTENT STEM CELL BIOLOGY AND PLURIPOTENT STATE TRANSITION

MICRORNA FUNCTION IN CELLULAR IRON HOMEOSTASIS

MICRORNA FUNCTION IN CELLULAR STRESS RESPONSE

(STEM) CELL QUANTITATIVE/FUNCTIONAL BIOLOGY AT SINGLE CELL RESOLUTION

HARNESSING MOLECULAR AND GENOMIC APPROACHES TO ILLUMINATE HUMAN LIVER PATHOBIOLOGY AT SINGLE MOLECULE RESOLUTION

DEVELOPMENT OF METHODS/TOOLS TO STUDY RNA/MICRORNAS/ OTHER POST-TRANSCRIPTIONAL REGULATORS IN HUMAN LIVER DEVELOPMENT AND DISEASE

TRANSLATIONAL: ERYTHROCYTE MICRORNA PROFILING LEADS TO PROMISING MECHANISM/THERAPEUTIC TARGET FOR PATIENTS WITH SICKLE CELL DISEASE

TRANSLATIONAL: METHOD FOR ERYTHROCYTE MICRORNA PROFILING IN ANEMIA DISORDERS IDENTIFIES SPECIFIC DEFECT IN SICKLE CELL DISEASE ERYTHROCYTES AND ERYTHROID PROGENITORS