The Sangokoya Lab, (PI: Carolyn Sangokoya, MD, PhD) focuses on how post-transcriptional regulatory networks (RNA + RNA-binding proteins) drive cell fate, function, and plasticity. We use functional and spatial transcriptomics, quantitative cell biology, gene-editing, and biosensors to understand the role of iron (and more) in development and disease. We are developing functional ‘omic methods for understanding how post-transcriptional regulatory networks alter cell fate, function, and plasticity in 3D stem cell-based models and in mice.
Finally, we apply an RNA-based lens to better understand human liver tissue in health and disease. Our long term goals are to apply our findings to re-engineering cells for regenerative therapies and to innovating diagnostic liver pathology in the age of precision-based medicine.
Join, celebrate, and support our basic discovery and translational science.
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