The Sangokoya Lab, (PI: Carolyn Sangokoya, MD, PhD) focuses on how post-transcriptional regulatory networks (RNA + RNA-binding proteins) drive cell fate, function, and plasticity. We use functional and spatial transcriptomics, quantitative cell biology, gene-editing, and biosensors to understand the role of iron (and more) in basic cell biology, development, and disease. We are developing functional ‘omic methods for understanding how post-transcriptional regulatory networks alter cell fate, function, and plasticity in 3D stem cell-based models and in mice. We aim to use these findings to decode and further dissect cellular iron homeostasis in human cells and tissues in health, development, and disease.
Finally, we apply an RNA-based lens to better understand human liver tissue in health and disease. Our long term goals are to apply our findings to re-engineering cells for regenerative therapies and to innovating diagnostics in the age of precision-based medicine.
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